TY - BOOK ID - 145065754 TI - Role of Genomics in the Management of Hypertension AU - Mulatero, Paolo AU - Monticone, Silvia PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - atrial natriuretic peptide KW - T2238C variant KW - endothelial dysfunction KW - smooth muscle cells contraction KW - platelet aggregation KW - epigenetics KW - cardiovascular diseases KW - renin KW - low-renin KW - hypertension KW - mineralocorticoid receptor KW - genetics KW - aldosterone KW - essential hypertension KW - blood pressure KW - genome-wide association studies KW - exome microarray KW - next-generation sequencing KW - rare variants KW - rare-variants association testing KW - burden test KW - sequence kernel association test KW - hypokalemia KW - low renin hypertension KW - monogenic hypertension KW - Liddle syndrome KW - SCNN1A KW - SCNN1B KW - SCNN1G KW - non-coding RNA KW - micro RNA KW - primary aldosteronism KW - aldosterone-producing adenoma KW - transcriptome profiing KW - DNA methylation KW - histone modifications KW - vascular smooth muscle cells KW - endothelial cells KW - Kruppel-like factor 15 KW - left ventricular hypertrophy KW - cardiac hypertrophy KW - heart failure KW - genetics of left ventricular hypertrophy KW - fibromuscular dysplasia KW - non atherosclerotic vascular stenosis KW - PHACTR1 KW - genetic association KW - cervical artery dissection KW - spontaneous coronary arteries dissection KW - CRY1 KW - CRY2 KW - HSD3B1 KW - HSD3B2 KW - cardio-tonic steroids KW - endogenous ouabain KW - adducin KW - renal damage KW - African American KW - ARMC5 KW - GRK4 KW - CACNA1D KW - endocrine hypertension KW - atrial natriuretic peptide KW - T2238C variant KW - endothelial dysfunction KW - smooth muscle cells contraction KW - platelet aggregation KW - epigenetics KW - cardiovascular diseases KW - renin KW - low-renin KW - hypertension KW - mineralocorticoid receptor KW - genetics KW - aldosterone KW - essential hypertension KW - blood pressure KW - genome-wide association studies KW - exome microarray KW - next-generation sequencing KW - rare variants KW - rare-variants association testing KW - burden test KW - sequence kernel association test KW - hypokalemia KW - low renin hypertension KW - monogenic hypertension KW - Liddle syndrome KW - SCNN1A KW - SCNN1B KW - SCNN1G KW - non-coding RNA KW - micro RNA KW - primary aldosteronism KW - aldosterone-producing adenoma KW - transcriptome profiing KW - DNA methylation KW - histone modifications KW - vascular smooth muscle cells KW - endothelial cells KW - Kruppel-like factor 15 KW - left ventricular hypertrophy KW - cardiac hypertrophy KW - heart failure KW - genetics of left ventricular hypertrophy KW - fibromuscular dysplasia KW - non atherosclerotic vascular stenosis KW - PHACTR1 KW - genetic association KW - cervical artery dissection KW - spontaneous coronary arteries dissection KW - CRY1 KW - CRY2 KW - HSD3B1 KW - HSD3B2 KW - cardio-tonic steroids KW - endogenous ouabain KW - adducin KW - renal damage KW - African American KW - ARMC5 KW - GRK4 KW - CACNA1D KW - endocrine hypertension UR - https://www.unicat.be/uniCat?func=search&query=sysid:145065754 AB - Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field. ER -