TY - BOOK ID - 14308528 TI - DNA Helicases and DNA Motor Proteins PY - 2013 SN - 1461450365 1461450373 128386505X 1489998519 PB - New York, NY : Springer New York : Imprint: Springer, DB - UniCat KW - Bacterial genetics. KW - DNA helicases. KW - DNA polymerases. KW - Isomerases KW - Adenosine Triphosphatases KW - Multiprotein Complexes KW - Acid Anhydride Hydrolases KW - Enzymes KW - Macromolecular Substances KW - Enzymes and Coenzymes KW - Hydrolases KW - Chemicals and Drugs KW - Molecular Motor Proteins KW - DNA Helicases KW - Medicine KW - Human Anatomy & Physiology KW - Biology KW - Health & Biological Sciences KW - Animal Biochemistry KW - Genetics KW - Pathology KW - DNA-protein interactions. KW - DNA-protein binding KW - Interactions, DNA-protein KW - Protein-DNA interactions KW - Helicases, DNA KW - Medicine. KW - Human genetics. KW - Biochemistry. KW - Cell biology. KW - Biomedicine. KW - Human Genetics. KW - Biochemistry, general. KW - Cell Biology. KW - Biomedicine general. KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Medical sciences KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Clinical sciences KW - Medical profession KW - Life sciences KW - Physicians KW - Composition KW - DNA-ligand interactions KW - Protein binding KW - Cytology. KW - Health Workforce KW - Biomedicine, general. UR - https://www.unicat.be/uniCat?func=search&query=sysid:14308528 AB - In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studiesĀ the editorsĀ aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system. ER -