TY - BOOK ID - 14307316 TI - Stimulation of trigeminal afferents improves motor recovery after facial nerve injury : functional, electrophysiological and morphological proofs PY - 2013 SN - 03015556 SN - 3642333109 3642333117 128394555X PB - Berlin : Springer, DB - UniCat KW - Face -- Surgery. KW - Facial bones -- Surgery. KW - Facial nerve -- Wounds and injuries -- Prevention. KW - Facial nerve KW - Biological Science Disciplines KW - Cranial Nerves KW - Peripheral Nerves KW - Natural Science Disciplines KW - Disciplines and Occupations KW - Peripheral Nervous System KW - Nervous System KW - Anatomy KW - Facial Nerve KW - Physiology KW - Trigeminal Nerve KW - Medicine KW - Surgery & Anesthesiology KW - Zoology KW - Health & Biological Sciences KW - Surgery - General and By Type KW - Neurology KW - Animal Anatomy & Embryology KW - Surgery KW - Face KW - Trigeminal nerve KW - Wounds and injuries KW - Treatment. KW - Movement disorders. KW - Diseases. KW - Facial dyskinesias KW - Facial movement disorders KW - Medicine. KW - Neurosciences. KW - Neurosurgery. KW - Biomedicine. KW - Movement disorders KW - Nerves, Cranial KW - Diseases KW - Nerves KW - Neurosurgery KW - Neural sciences KW - Neurological sciences KW - Neuroscience KW - Medical sciences KW - Nervous system KW - Neuroscience. KW - Surgery. UR - https://www.unicat.be/uniCat?func=search&query=sysid:14307316 AB - Its is commonly known that the recovery of mimic functions after facial nerve injury is poor: a successful regrowth of the lesioned axons to their muscle targets is compromised by (i) poor navigation of the growth cones and excessive collateral axonal branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to the facial neuronal cell bodies in the brainstem. As a result, axotomized motoneurons become hyperexcitable and unable to discharge. Since the improvement of growth cone navigation and the reduction of the ephaptic cross-talk between axons both turn out be impossible at present, the authors focused their efforts on the third detrimental component and proposed that an intensification of the trigeminal input to the axotomized and electrophysiologically silent facial motoneurons might improve the specificity of reinnervation. To test their hypothesis, they compared behavioral, electrophysiological and morphological parameters after single reconstructive surgery on the facial nerve (or its buccal branch) with those obtained after identical facial nerve surgery but combined with indirect (removal of the contralateral infraorbital nerve, ION) or direct (massage of the mimic muscles) stimulation of the ipsilateral ION. They found that in all cases any trigeminal stimulation was beneficial for the outcome by improving both the quality of target reinnervation (reduced polyinnervation of the motor endplates) and the recovery of vibrissal motor performance (as judged by video-based motion analysis). Based on these results, the authors conclude that trigeminal stimulation is a non-invasive procedure with immediate potential for clinical rehabilitation following facial nerve reconstruction. ER -