TY - BOOK ID - 14306027 TI - Tumour-associated macrophages AU - Lawrence, Toby. AU - Hagemann, Thorsten. PY - 2012 SN - 1461406617 9786613353313 1461406625 1283353318 PB - New York : Springer, DB - UniCat KW - Cancer -- Research. KW - Macrophages. KW - Tumors. KW - Macrophages KW - Tumors KW - Immunology KW - Cancer KW - Disease Attributes KW - Mononuclear Phagocyte System KW - Phagocytes KW - Connective Tissue Cells KW - Myeloid Cells KW - Diseases KW - Cells KW - Immune System KW - Pathologic Processes KW - Anatomy KW - Pathological Conditions, Signs and Symptoms KW - Hemic and Immune Systems KW - Neoplasms KW - Disease Progression KW - Biology KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Microbiology & Immunology KW - Growth KW - Immunological aspects KW - Tumours KW - Histiocytes KW - Mononuclear phagocytes KW - Medicine. KW - Cancer research. KW - Pharmacology. KW - Biomedicine. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - Pathology KW - Cysts (Pathology) KW - Antigen presenting cells KW - Connective tissue cells KW - Killer cells KW - Reticulo-endothelial system UR - https://www.unicat.be/uniCat?func=search&query=sysid:14306027 AB - Macrophages are tissue resident phagocytes that have important roles in development and immunity. The observation that cancers become infiltrated by large numbers of macrophages was first made by Virchow in 1863, clinical and experimental studies suggest tumor-associated macrophages (TAM) are critical to promote carcinogenesis and tumor-progression, however to this day it still isn’t clear what regulates the recruitment of macrophages in tumors and what drives their pro-tumor functions. This volume will provide an overview of current research on the form and function of TAM, highlighting both the mechanistic roles they play in carcinogenesis and tumor progression as well as the molecular mechanisms that control their phenotype and function, and the final chapter addresses the issue of TAM as a potential target in cancer therapy. ER -