TY - BOOK ID - 14301982 TI - Biophysics of DNA-protein interactions : from single molecules to biological systems AU - Williams, Mark C. AU - Maher, L. James PY - 2011 SN - 0387928073 9786612973840 1282973843 0387928081 PB - New York : Springer, DB - UniCat KW - DNA-protein interactions. KW - DNA-protein interactions KW - Molecular biology KW - Physical Phenomena KW - Proteins KW - Phenomena and Processes KW - Amino Acids, Peptides, and Proteins KW - DNA-Binding Proteins KW - Biophysical Phenomena KW - Chemicals and Drugs KW - Human Anatomy & Physiology KW - Biology KW - Health & Biological Sciences KW - Animal Biochemistry KW - Biophysics KW - Molecular biology. KW - Molecular biochemistry KW - Molecular biophysics KW - DNA-protein binding KW - Interactions, DNA-protein KW - Protein-DNA interactions KW - Physics. KW - Biochemistry. KW - Proteins. KW - Cell biology. KW - Biophysics. KW - Biological physics. KW - Biomedical engineering. KW - Biophysics and Biological Physics. KW - Molecular Medicine. KW - Cell Biology. KW - Biomedical Engineering. KW - Biochemistry, general. KW - Protein Structure. KW - Biochemistry KW - Biomolecules KW - Systems biology KW - DNA-ligand interactions KW - Protein binding KW - Medicine. KW - Cytology. KW - Biological and Medical Physics, Biophysics. KW - Biomedical Engineering and Bioengineering. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Medical sciences KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Engineering KW - Medicine KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Pathology KW - Physicians KW - Composition KW - Health Workforce KW - Proteins . KW - Proteids KW - Polypeptides KW - Proteomics KW - Biological physics KW - Physics UR - https://www.unicat.be/uniCat?func=search&query=sysid:14301982 AB - This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity. ER -