TY - BOOK ID - 14299819 TI - Hepatobiliary and pancreatic carcinogenesis in the hamster AU - Tajima, Yoshitsugu. AU - Kanematsu, Takashi. AU - Kuroki, Tamotsu. PY - 2009 SN - 443187772X 9786611986926 1281986925 4431877738 PB - Tokyo : Springer Japan, DB - UniCat KW - Animal Physiology. KW - Cancer -- Animal models. KW - Cytology -- Technique. KW - Biliary Tract Neoplasms KW - Pancreatic Neoplasms KW - Cricetinae KW - Liver Neoplasms KW - Models, Animal KW - Carcinoma KW - Pancreatic Diseases KW - Digestive System Neoplasms KW - Muridae KW - Endocrine Gland Neoplasms KW - Neoplasms, Glandular and Epithelial KW - Investigative Techniques KW - Liver Diseases KW - Biliary Tract Diseases KW - Endocrine System Diseases KW - Digestive System Diseases KW - Neoplasms by Histologic Type KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Neoplasms by Site KW - Rodentia KW - Diseases KW - Neoplasms KW - Mammals KW - Vertebrates KW - Chordata KW - Animals KW - Eukaryota KW - Organisms KW - Oncology KW - Gastroenterology KW - Medicine KW - Health & Biological Sciences KW - Liver KW - Biliary tract KW - Pancreas KW - Animal models. KW - Biliary tree KW - Medicine. KW - Cancer research. KW - Hepatology. KW - Surgical oncology. KW - Animal anatomy. KW - Animal physiology. KW - Biology KW - Biomedicine. KW - Cancer Research. KW - Biological Techniques. KW - Animal Anatomy / Morphology / Histology. KW - Surgical Oncology. KW - Technique. KW - Digestive organs KW - Endocrine glands KW - Exocrine glands KW - Bile KW - Abdomen KW - Oncology. KW - Cytology KW - Morphology (Animals). KW - Clinical medicine. KW - Research KW - Methodology. KW - Cancer KW - Oncologic surgery KW - Oncological surgery KW - Surgical oncology KW - Medicine, Clinical KW - Animal physiology KW - Anatomy KW - Animal morphology KW - Body form in animals KW - Zoology KW - Morphology KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Tumors KW - Excision KW - Treatment KW - Physiology KW - Biology—Technique. KW - Animal anatomy KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:14299819 AB - Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D. ER -