TY - BOOK ID - 14296136 TI - Dendritic Cells AU - Lombardi, Giovanna. AU - Riffo-Vasquez, Yanira. PY - 2009 SN - 3540710280 3642090079 9786611913908 1281913901 3540710299 PB - Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, DB - UniCat KW - Dendritic Cells -- drug effects. KW - Dendritic Cells -- immunology. KW - Immunopathology. KW - Dendritic cells KW - Immunopathology KW - Antigen-Presenting Cells KW - Epithelial Cells KW - Mononuclear Phagocyte System KW - Immunomodulation KW - Immune System KW - Cells KW - Biological Therapy KW - Anatomy KW - Hemic and Immune Systems KW - Therapeutics KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Dendritic Cells KW - Immunotherapy KW - Health & Biological Sciences KW - Biology KW - Microbiology & Immunology KW - Pharmacy, Therapeutics, & Pharmacology KW - Dendritic cells. KW - Follicular dendritic cells KW - Interdigitating cells KW - Medicine. KW - Cancer research. KW - Immunology. KW - Laboratory medicine. KW - Medical microbiology. KW - Pharmacology. KW - Oncology. KW - Biomedicine. KW - Pharmacology/Toxicology. KW - Cancer Research. KW - Laboratory Medicine. KW - Medical Microbiology. KW - Antigen presenting cells KW - Lymphoid tissue KW - Clinical immunology KW - Pathology KW - Toxicology. KW - Oncology . KW - Medical laboratories. KW - Microbiology. KW - Microbial biology KW - Microorganisms KW - Diagnosis, Laboratory KW - Health facilities KW - Laboratories KW - Immunobiology KW - Life sciences KW - Serology KW - Tumors KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Toxicology KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Clinical medicine KW - Clinical pathology KW - Diagnostic laboratory tests KW - Laboratory diagnosis KW - Laboratory medicine KW - Medical laboratory diagnosis KW - Diagnosis KW - Cancer research KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:14296136 AB - The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological conditions. The actual applicability and therapeutic potential of all these approaches is yet to be fully demonstrated but nonetheless, animal models of human diseases are proving to be very helpful in the evaluation of manipulated DCs as a new treatment in diseases like cancer, auto- munity or asthma. DCs are integral to the initiation and regulation of immune response (Banchereau et al. 2000). The outcome of antigen presentation by DCs is determined by their maturation status, which can be induced by their interaction with danger signals. To recognise a wide array of pathogen-associated molecular patterns (PAMP), DCs express a number of pattern recognition receptors (PRR) such as Toll-like rec- tors (TLRs) and C-type lectin receptors (CLR) that recognise structural components of pathogens and discriminate between self and non-self molecules. ER -