TY - BOOK ID - 14296105 TI - cGMP : generators, effectors and therapeutic implications AU - Antos, L. K. AU - Hofmann, Franz AU - Schmidt, Harald H. H. W. AU - Stasch, Johannes-Peter. PY - 2009 SN - 3540689605 3642088481 9786611955083 1281955086 3540689648 PB - [Berlin, Germany?] : Springer, DB - UniCat KW - Biochemistry. KW - Cyclic adenylic acid. KW - Cyclic GMP. KW - Cyclic guanylic acid. KW - Medicine. KW - Protein kinase --Metabolism --Collected works. KW - Protein kinases. KW - Nucleotides, Cyclic KW - Guanine Nucleotides KW - Purine Nucleotides KW - Ribonucleotides KW - Nucleotides KW - Nucleic Acids, Nucleotides, and Nucleosides KW - Purines KW - Chemicals and Drugs KW - Heterocyclic Compounds, 2-Ring KW - Heterocyclic Compounds KW - Cyclic GMP KW - Health & Biological Sciences KW - Human Anatomy & Physiology KW - Pharmacy, Therapeutics, & Pharmacology KW - Animal Biochemistry KW - Cyclic nucleotides. KW - cGMP (Biochemical) KW - Cyclic guanosine monophosphate KW - Guanosine cyclic monophosphate KW - Guanylic acid, Cyclic KW - Life sciences. KW - Human physiology. KW - Molecular biology. KW - Pharmacology. KW - Medical biochemistry. KW - Life Sciences. KW - Biochemistry, general. KW - Pharmacology/Toxicology. KW - Medical Biochemistry. KW - Human Physiology. KW - Molecular Medicine. KW - Cyclic nucleotides KW - Toxicology. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Physiology KW - Human body KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Toxicology KW - Composition KW - Health Workforce KW - Pharmacologies KW - Pharmaceutical Preparations KW - pharmacology KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Medical biochemistry KW - Pathobiochemistry KW - Pathological biochemistry KW - Drug effects KW - Medical pharmacology KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:14296105 AB - After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic. ER -