TY - BOOK ID - 14296065 TI - Antiviral strategies AU - Bartenschlager, Ralf. AU - Krausslich, Hans-Georg. PY - 2008 SN - 3540790853 3642097952 9786611920708 1281920703 3540790861 PB - Berlin : Springer, DB - UniCat KW - Antiviral agents. KW - Pharmacology. KW - Virus diseases -- Chemotherapy. KW - Virus Diseases -- drug therapy. KW - Diseases KW - Anti-Infective Agents KW - Therapeutic Uses KW - Pharmacologic Actions KW - Chemical Actions and Uses KW - Chemicals and Drugs KW - Antiviral Agents KW - Virus Diseases KW - Health & Biological Sciences KW - Pharmacy, Therapeutics, & Pharmacology KW - Virus diseases KW - Chemotherapy. KW - Antiviral drugs KW - Antivirals KW - Medicine. KW - Gene therapy. KW - Drug resistance. KW - Pharmaceutical technology. KW - Virology. KW - Biomedicine. KW - Pharmacology/Toxicology. KW - Pharmaceutical Sciences/Technology. KW - Drug Resistance. KW - Gene Therapy. KW - Antiviral agents KW - Anti-infective agents KW - Virus inhibitors KW - Chemotherapy KW - Toxicology. KW - Medical virology. KW - Drug interactions. KW - Therapy, Gene KW - Genetic engineering KW - Therapeutics KW - Interactions, Drug KW - Drugs KW - Pharmaceutical laboratory techniques KW - Pharmaceutical laboratory technology KW - Technology, Pharmaceutical KW - Technology KW - Medical microbiology KW - Virology KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Side effects KW - Toxicology KW - Resistance to drugs KW - Microbiology KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Pharmacy KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:14296065 AB - A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development. ER -