TY - BOOK ID - 14295616 TI - Cell and tissue reaction engineering AU - Eibl, Regine. AU - Fusenegger, Martin. AU - Weber, Wilfried. PY - 2009 SN - 3540681752 3642018742 3540681825 PB - Berlin : Springer, DB - UniCat KW - Cell culture -- Industrial applications. KW - Cell Culture Techniques. KW - Cells. KW - Cytological Techniques. KW - Genetic Techniques. KW - Mammals -- Cytology -- Technique. KW - Medical informatics. KW - Molecular Biology. KW - Tissue engineering. KW - Tissue engineering KW - Culture Techniques KW - Clinical Laboratory Techniques KW - Investigative Techniques KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Tissue Engineering KW - Biology KW - Health & Biological Sciences KW - Cytology KW - Biomedical Engineering KW - Life sciences. KW - Pharmaceutical technology. KW - Biotechnology. KW - Biochemical engineering. KW - Cell biology. KW - Cell culture. KW - Biomedical engineering. KW - Life Sciences. KW - Cell Culture. KW - Biochemical Engineering. KW - Biomedical Engineering. KW - Pharmaceutical Sciences/Technology. KW - Cell Biology. KW - Biomedical engineering KW - Regenerative medicine KW - Tissue culture KW - Cytology. KW - Biomedical Engineering and Bioengineering. KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Pharmaceutical laboratory techniques KW - Pharmaceutical laboratory technology KW - Technology, Pharmaceutical KW - Technology KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Biophysics KW - Engineering KW - Medicine KW - Chemical engineering KW - Genetic engineering KW - Bio-process engineering KW - Bioprocess engineering KW - Biochemistry KW - Biotechnology KW - Cultures (Biology) KW - Technique KW - Pharmaceutical chemistry. KW - Chemical Bioengineering. KW - Pharmaceutics. KW - Technique. KW - Chemistry, Medical and pharmaceutical KW - Chemistry, Pharmaceutical KW - Drug chemistry KW - Drugs KW - Medical chemistry KW - Medicinal chemistry KW - Pharmacochemistry KW - Chemistry UR - https://www.unicat.be/uniCat?func=search&query=sysid:14295616 AB - The completion of the Human Genome Project and the rapid progress in cell biology and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free culture media, disposables and the implications of changing processes (multi-purpose- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a comprehensive overview of the literature. This has been done extensively elsewhere. ER -