TY - BOOK ID - 14201844 TI - Capillary fluid exchange : regulation, functions, and pathology AU - Scallan, Joshua. AU - Huxley, Virgina H. AU - Korthuis, Ronald J. PY - 2010 SN - 1615040668 1615040676 PB - [San Rafael, Calif.?] : Morgan & Claypool, DB - UniCat KW - Cardiovascular system. KW - Biological transport. KW - Capillaries KW - Microcirculation. KW - Extracellular fluid. KW - Lymphatics. KW - Edema. KW - Capillary Permeability. KW - Permeability. KW - Starling equation KW - Capillary filtration KW - Permeability KW - Microvascular network KW - Extracellular matrix KW - Intersitital flow KW - Lymphatics KW - Edema KW - Edema safety factors UR - https://www.unicat.be/uniCat?func=search&query=sysid:14201844 AB - The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. ER -