TY - THES ID - 138843637 TI - Characteristics of Full-Field Electroretinography in Autoimmune Retinopathies AU - Ni, Boën AU - Jacob, Julie AU - Balikova, Irina AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Leuven) PY - 2022 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:138843637 AB - ABSTRACT Background: Autoimmune retinopathies (AIR) are a group of disorders that are characterized by autoantibodies targeting crucial retinal proteins, leading to vision loss. Diagnosis relies on visual symptoms, identification of autoantibodies and electrophysiological changes. However, diagnosis remains challenging due to the rare nature of AIR and the lack of disease-specific features during testing. Objectives: Our objective was to identify the characteristics of full-field electroretinography (ffERG) in cancer-associated (CAR), melanoma-associated (MAR) and non-paraneoplastic autoimmune retinopathy (npAIR). Methods: A systematic search in PubMed yielded 94 case reports and case series describing ffERG findings in 322 patients with CAR, MAR or npAIR. We analyzed individual parameter distribution per ffERG protocol, wave amplitudes of different ffERG protocols and ffERG response symmetry between eyes, for the three AIR groups. Results: We provided evidence that CAR and npAIR subjects display a wide range of ffERG profiles, though simultaneous scotopic and photopic dysfunction were frequent, ranging from reduced to extinguished responses. On the contrary, the findings of MAR patients were much more homogenous. An electronegative rod-cone combined ERG pattern was dominant in MAR patients and indicate an impaired ON-bipolar cell function. Asymmetrical ERG findings were found in some patients with AIR, as expected. Symmetry was most notable in the MAR group. Conclusion: This systematic review indicates different ffERG profiles for the three subgroups of autoimmune retinopathy. CAR and npAIR share varying degrees of severity and features. These joint features could possibly be explained by the presence of overlapping candidate antiretinal antibodies that have been associated with both CAR and npAIR. Whereas with MAR, a specific electronegative combined response can be expected together with positive anti-ON bipolar antibodies. Antibody testing and electroretinography are complementary and should not be held back when a patient presents itself with sudden vision loss and unremarkable findings with other ophthalmological tests. ER -