TY - BOOK ID - 138839744 TI - Biomaterial-Related Infections AU - Rodrigues, Célia F. AU - Martins, Natália PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Candida KW - biofilms KW - diabetes KW - medical devices KW - candidiasis KW - metabolic disorder KW - hyperglycemia KW - infection KW - Candida glabrata KW - candidemia KW - echinocandins KW - resistance KW - micafungin KW - caspofungin KW - in vivo KW - titanium dioxide KW - nanotubes KW - autoclaving KW - titanium alloy KW - biocompatibility KW - wettability KW - mechanical properties KW - silver nanoparticles KW - titanium dioxide nanotubes KW - silver ions release KW - biointegration KW - antimicrobial activity KW - polyethylene terephthalate KW - PET KW - electrospinning KW - nanofibers KW - antimicrobial agents KW - Taguchi method KW - antimicrobial efficiency KW - cold atmospheric-pressure plasma jet (CAPJ) KW - Escherichia coli KW - DNA double-strand breaks KW - scanning electron microscopy KW - Ti6Al4V implants KW - anodization process KW - XPS KW - genotoxicity assessment KW - anti-inflammatory properties KW - oral biofilm KW - infection control KW - Streptococcus mutans KW - Candida spp. KW - natural compounds KW - antimicrobial resistance KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:138839744 AB - The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration. ER -