TY - BOOK ID - 138470538 TI - The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - calorie restriction diet KW - body mass reduction KW - insulin KW - IGF-1 KW - leptin KW - adiponectin KW - malnutrition KW - heart impairment KW - papillary muscle assay KW - calcium transient proteins KW - SERCA2a KW - L-type calcium channel KW - aging KW - autophagy KW - calorie restriction (CR) KW - CR mimetic KW - calorie restriction KW - FoxO transcription factor KW - sirtuin KW - neuropeptide Y KW - pleiotropy of CR genes KW - senescence-associated secretory phenotype KW - senoinflammation KW - mimetics KW - intermittent fasting KW - fat mass KW - insulin secretion KW - pancreatic islet KW - lifespan KW - longevity KW - fasting KW - skin aging KW - photoaging KW - skin appendages KW - caloric restriction KW - fatty acid biosynthesis KW - mitochondrial biogenesis KW - adipocyte KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:138470538 AB - Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases. ER -