TY - THES ID - 138410099 TI - The value of ambulatory blood pressure monitoring in children with autosomal dominant polycystic kidney disease AU - Lowie, Lien AU - Mekahli, Djalila AU - Dachy, Angélique AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Leuven) PY - 2021 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:138410099 AB - Background The importance of ambulatory blood pressure monitoring (ABPM) for diagnosing hypertension in children with autosomal dominant polycystic kidney disease (ADPKD) has recently been demonstrated. However, extensive data on hypertension profiles in ADPKD children are lacking. This study is the first to focus on the prevalence of masked hypertension, white coat hypertension and sustained hypertension on ABPM in ADPKD children. Methods We conducted a retrospective study on ABPM data in a pediatric ADPKD cohort (<19 years). Demographics and clinical data were collected together with the blood pressure measurements from the outpatients clinic (BPc) and from ABPM. The hypertension phenotypes were diagnosed by comparing BPc to ABPM findings. Repetitive ABPM records from the same patients were also analyzed. Results 59 patients with a mean age of 10.8 ± 3.8 years were included. On ABPM data, hypertension was diagnosed in 19% of patients. Comparing ABPM data to BPc showed white coat hypertension, masked hypertension and sustained hypertension in 10%, 12% and 7% of all patients respectively. Repetitive ABPM records were performed in 30 patients (51%). White coat, masked and sustained hypertension newly emerged on these records in 14%, 7% and 11% of patients, respectively. Conclusion ABPM is the golden standard for the correct diagnosis and monitoring of hypertension in ADPKD children. Moreover, we demonstrated that ABPM is also very important in detecting masked hypertension and white coat hypertension which can influence the treatment of these children. Repetitive ABPM records should be considered, since new hypertension phenotypes may arise at later records. ER -