TY - BOOK ID - 138351866 TI - Extension of Healthy Life Span of Dialysis Patients in the Era of a 100-Year Life AU - Inaba, Masaaki AU - Mori, Katsuhiko PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - hypertension KW - body weight KW - mortality KW - sodium KW - dialysis KW - malnutrition KW - protein energy wasting (PEW) KW - sarcopenia KW - carnitine KW - carnitine deficiency KW - end-stage kidney disease KW - peritoneal dialysis KW - hemodialysis KW - frailty KW - protein energy wasting KW - hypercatabolism KW - renal rehabilitation KW - exercise KW - sarcopenia and frailty KW - nutritional support KW - protein synthesis KW - muscle physiology KW - physical activity KW - exercise tolerance KW - quality of life KW - skeletal muscle KW - aging KW - chronic kidney disease KW - diabetes KW - CKD-MBD KW - FGF23 KW - aKlotho KW - phosphate-binder KW - zinc KW - cardiovascular disease KW - potassium KW - potassium excretion KW - blood pressure KW - salt KW - CKD KW - fat mass KW - visceral fat KW - subcutaneous fat KW - nutrition KW - body mass index KW - obesity paradox KW - magnetic resonance imaging KW - diffusion tensor imaging KW - arterial spin labeling KW - blood oxygenation level-dependent KW - nutritional status KW - dialysis patients KW - clinical malnutrition KW - older individuals KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:138351866 AB - Malnutrition is becoming a more prominent health problem, with an increasing number of elderly CKD patients being put on dialysis. In addition, the presence of inflammation, sarcopenia/frailty, diabetes, and CVD is a definite and independent risk factor associated with higher mortality in this population. Although the restriction of protein intake has been recommended to protect eGFR decline, hyperphosphatemia, and hyperkalemia in CKD patients, it might accelerate the loss of skeletal muscle and adipose mass, leading to a poor prognosis. Therefore, flexible responses are considered regarding whether protein restriction should be continued or loosened in pre-dialysis CKD patients. In undernourished elderly patients undergoing hemodialysis, sufficient calorie/protein intake is necessary to counteract the development of sarcopenia/frailty. It is expected that the application of new drugs including phosphate binders and potassium chelators may achieve both a high enough intake and balanced levels of phosphate and potassium. Furthermore, the improvement of deficient micronutrients and poor appetite is also necessary. Comprehensive care is essential for the wellbeing of elderly patients undergoing hemodialysis. The topicof this Special Issue is “Extension of Healthy Life Span of Dialysis Patients in the Era of a 100-Year Life”. ER -