TY - BOOK ID - 137864913 TI - Centenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan AU - Puca, Annibale AU - Caruso, Calogero PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - aging KW - alternative therapy KW - composition of royal jelly KW - dietary interventions KW - healthspan KW - lifespan KW - longevity KW - royal jelly KW - IGF-1 KW - oxidative stress KW - ageing KW - nematode KW - immunosenescence KW - probiotic bacteria KW - pathogen protection KW - food allergy KW - elderly KW - hypersensitivity KW - gut KW - allergy KW - inflammation KW - redoxomics KW - glutathione KW - meniere’s disease KW - neurodegenerative diseases KW - healthy aging KW - DNA methylation KW - epigenetic clocks KW - telomere length KW - centenarians KW - exosomes KW - serum KW - functional enrichment analysis KW - ingenuity pathway analysis KW - miRNA-mRNA networks KW - aging-related disease KW - Di (2-Ethylhexyl) pthalate KW - Hericium erinaceus KW - vitagenes KW - apoptosis KW - mitochondrial respiratory complexes KW - C. elegans KW - polyphenols KW - olive oil KW - Parkinson’s disease KW - β-Dystroglycan KW - cellular senescence KW - lamin B1 KW - DNA-damage response KW - defective mitosis KW - n/a KW - meniere's disease KW - Parkinson's disease UR - https://www.unicat.be/uniCat?func=search&query=sysid:137864913 AB - People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine. ER -