TY - THES ID - 137832357 TI - Prevalence and prognostic impact of iron deficiency following cardiac transplantation AU - Brackenier, Cedric AU - Van Cleemput, Johan AU - Van Aelst, Lucas AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Geen nieuwe inschrijvingen vanaf 2015-2016) (Leuven) PY - 2018 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:137832357 AB - Background Iron deficiency (ID) is common in heart failure (HF) and associated with impaired functional outcome and increased mortality. No data exist on the prevalence of ID early following heart transplantation (HTX) and its functional outcome. The aim of this study is to describe the prevalence of ID, the evolution of iron parameters following HTX and to investigate the relation between iron status and functional outcome one year following HTX. Methods In this single-center, retrospective study, all patients who underwent HTX from April 2003 until July 2016 (n = 312) were included. Demographic and clinical variables, iron parameters (ferritin and transferrin saturation) at 6 weeks, 3 months and 1 year and a 6-min walk test (6MWD) as functional surrogate at 1 year following HTX were collected. Results At 6 weeks, 3 months and 1 year following HTX, median ferritin levels were 112.5 μg/L, 81 μg/L and 92 μg/L respectively; 52%, 66% and 61% of patients were iron deficient. No significant difference in 6MWD between patients with and without ID was present (p = 0.90). In univariate analysis, 6MWD was negatively correlated with ferritin at one year following HTX (r = -0.15, p = 0.05), recipient age (r = -0.35, p < 0.01) and BMI (r = -0.21, p < 0.01) whereas in multivariate analysis, only age (r = -0.31, p < 0.01) and BMI (r = -0.18, p = 0.02) remained correlated. Conclusion ID is highly prevalent early after HTX but is not associated with 6MWD one year after HTX. Recipient age and BMI are inversely correlated with 6MWD in multivariate analysis. ER -