TY - BOOK ID - 137712781 TI - The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria AU - Broutin, Isabelle AU - Vargiu, Attilio V AU - Venter, Henrietta AU - Phan, Gilles PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - MdtF (YhiV) KW - multidrug resistance KW - RND-type efflux pump KW - dye accumulation KW - real-time efflux KW - pathogens KW - RND KW - evolution KW - efflux pump KW - adaptation KW - Aliarcobacter butzleri KW - RND efflux pumps KW - virulence KW - resistance KW - RND pump KW - dominant negative effect KW - assembly KW - protein-protein interaction KW - mutation KW - drug resistance KW - cystic fibrosis KW - prevalence of efflux resistance mechanisms KW - hospital acquired infections KW - antibiotic resistance KW - allostery KW - antimicrobial resistance KW - conformational changes KW - energetic transition KW - gram-negative bacteria KW - pump activation KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:137712781 AB - Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. ER -