TY - THES ID - 137690665 TI - Mid-term outcome of doxycycline sclerotherapy in lymphatic malformations of the head-neck region AU - Maleux, Olivia AU - Hens, Greet AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Leuven) PY - 2020 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:137690665 AB - ABSTRACT Background Lymphatic malformation (LM) is a rare congenital condition. This vascular anomaly mainly occurs in the head and neck region and may cause esthetic complaints/deformity and airway compromise. Complete excision is often not possible, as the malformation is extending around vessels and nerves. In macrocystic lesions, percutaneous sclerotherapy is considered a valuable treatment option. Objective To evaluate the safety, efficacy and durability of ultrasound-guided sclerotherapy with doxycycline in LM in the head and neck region. Materials and methods We conducted a retrospective study of consecutive patients treated for LM with doxycycline sclerotherapy over a 9-year period (2010-2019). Data collection included patient demographics, presentation details as size, location, side and classification; number of procedures, amount of doxycycline injected and type of anesthesia. The available imaging, including MRI, angiography and US were reviewed. Outcome was evaluated using the medical reports of the last follow-up appointments taking into account clinical improvement, ultrasound measurements and possible complications. Results Over a 9-year period (2010-2019), 27 patients (14 M, 13F) underwent a total amount of 103 sclerotherapy procedures for congenital head and neck LM. Patients underwent a mean of four sclerotherapy sessions. Two out of 27 patients presented with a minor complication, one patient with a post-procedural major complication. The mean total dose of injected doxycycline was 170 mg. 85.19% of the patients obtained an excellent result, 11.11% were satisfied with the result over a mean follow-up period of 40 months. In one patient, sclerotherapy did not have the wished-for outcome. Conclusion Ultrasound-guided, percutaneous doxycycline sclerotherapy is an effective and durable treatment in LM with a low complication rate. ER -