TY - BOOK ID - 137681259 TI - Mitochondria-targeted drug delivery PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - retinal ischemia KW - blood–brain barrier KW - endothelial KW - reactive oxygen species KW - oxidative stress KW - tunneling nanotubules KW - neuron KW - central nervous system KW - inflammation KW - hypoxia KW - anticancer peptide (ACP) KW - antimicrobial peptide (AMP) KW - anticancer peptides KW - antimicrobial peptides KW - host defense peptides KW - prediction KW - random forest KW - mitochondria KW - mitochondrial DNA KW - mitochondrial disorders KW - pharmacological therapy KW - gene therapy KW - precision medicine KW - cardiovascular disease KW - drug delivery KW - mitochondria dysfunctions KW - nanocarriers KW - oxoglutarate carrier KW - malate-aspartate shuttle KW - cancer metabolism KW - ATP production KW - diphenyleneiodonium KW - NADPH-oxidase KW - differentiation KW - proliferation KW - mitochondria-targeted antioxidants KW - LPS KW - mitochondrial ROS KW - antitumor agents KW - fluorescence lifetime imaging KW - medicinal chemistry KW - metabolic drug KW - mitochondrial carrier KW - melanoma KW - plumbagin KW - cytotoxic effect KW - metabolism KW - cholesterol KW - lipid raft KW - mitochondrial permeability transition pore KW - alkylphospholipid analog KW - edelfosine KW - mitochondrial oncometabolites KW - cancer drug resistance KW - mitochondrial disease KW - heteroplasmy KW - mitochondrial gene delivery KW - n/a KW - blood-brain barrier UR - https://www.unicat.be/uniCat?func=search&query=sysid:137681259 AB - Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers. ER -