TY - BOOK ID - 136996045 TI - Actinomycetes : The Antibiotics Producers AU - Stegmann, Evi AU - Mast, Yvonne PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Streptomyces KW - biogeography KW - comparative genomics KW - diversification KW - secondary metabolite biosynthetic gene clusters KW - SMGC KW - natural products KW - streptomyces KW - rishirilide KW - biosynthesis KW - polyketides KW - polynucleotide phosphorylase KW - ribonuclease KW - regulation KW - promoter KW - RNA decay KW - polyadenylation KW - (p)ppGpp KW - antibiotic KW - antibiotics KW - geomicrobiology KW - Illumina sequencing KW - microbiome diversity KW - Actinobacteria KW - Cave microbiology KW - secondary metabolite KW - rare Actinobacteria KW - Amycolatopsis KW - unculturability KW - siderophore KW - glycopeptide antibiotics KW - dbv cluster KW - regulatory genes KW - StrR KW - LAL KW - LuxR solo KW - dalbavancin KW - A40926 KW - Streptomyces lividans KW - secretion pathways KW - secretory proteins KW - signal peptides KW - actinomycetes KW - teicoplanin KW - van resistance genes KW - Streptomyces tsukubaensis KW - tacrolimus KW - FK506 KW - omics KW - screening KW - secondary metabolism KW - differentiation KW - elicitors KW - morphology KW - liquid cultures KW - metagenomics KW - rare actinomycetes KW - dereplication KW - metabolomics KW - genome mining KW - secondary metabolites KW - novel compounds KW - physicochemical screening KW - physical and chemical properties KW - structural diversity KW - biological activity KW - Actinoallomurus KW - antibiotics polyethers KW - lysolipin KW - minimal PKS II KW - cyclases KW - benz[a]naphthacene quinone KW - tridecaketide KW - aromatic polyketide KW - pentacyclic angular polyphenol KW - extended polyketide chain KW - actinobacteria KW - β-lactamase KW - resistance KW - β-lactamase inhibitor KW - polyketide synthases KW - acyltransferases KW - engineering KW - new bioactive compounds KW - symbiosis KW - drug discovery KW - chemical ecology KW - culture-based approaches KW - strain KW - specialized metabolites KW - biosynthetic gene cluster KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:136996045 AB - Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes ER -