TY - BOOK ID - 136964608 TI - Mechanisms of Innate Neuroprotection PY - 2016 PB - Frontiers Media SA DB - UniCat KW - Neuroprotection KW - postconditioning KW - NCX KW - Stroke KW - seizure KW - miRNA KW - Alzheimer KW - preconditioning UR - https://www.unicat.be/uniCat?func=search&query=sysid:136964608 AB - As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans. ER -