TY - THES ID - 136570263 TI - The effect of weight reduction on disease activity in patients with chronic inflammatory arthritis AU - Hermans, Joppe AU - Verschueren, Patrick AU - Pazmiño Lucio, Sofia AU - De Meyst, Elias AU - Doumen, Michaël AU - Bertrand, Delphine AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Leuven) PY - 2023 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:136570263 AB - Background: Obesity and overweight are known risk factors for the development of rheumatic disease. Furthermore, these conditions may negatively impact disease evolution and therapeutic efficacy. Based on earlier research, the cause for these negative effects might be an accumulation of adipokines and pro-inflammatory cytokines in patients with obesity, leading to a chronic inflammatory state of the body. Some studies have evaluated the effects of intentional weight loss on rheumatic joint diseases. A systematic review would provide a more extensive in-depth view on this topic. Methods: We systematically searched in 7 databases (Medline, Embase, CINAHL database by EBSCO, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) and the Web of Science Core Collection) for relevant articles. Two independent reviewers screened the articles using the predetermined in- and exclusion criteria. Included studies examined patients with chronic i ER -