TY - BOOK ID - 136369758 TI - Peptide Nucleic Acids : Applications in Biomedical Sciences PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - RNA structure KW - strand invasion KW - antisense KW - PNA KW - exon skipping KW - exon inclusion KW - oligonucleotides KW - peptide nucleic acid (PNA) KW - antibacterials KW - RNA KW - PNA transporters KW - conjugates KW - bacterial resistance KW - peptide nucleic acids KW - triplex KW - gene editing KW - structure KW - recombination KW - repair KW - nanoparticles KW - β-thalassemia KW - cystic fibrosis KW - peptide nucleic acid KW - tolane KW - single nucleotide polymorphism KW - influenza virus KW - drug resistance KW - peptide nucleic acids (PNAs) KW - single-nucleotide polymorphism (SNP) KW - polymerase chain reaction (PCR) KW - cancer. KW - catalytic hairpin assembly (CHA) KW - strand-displacement reaction KW - l-DNA KW - microRNA KW - fluorescence KW - templated reactions KW - light-triggered KW - electrochemical biosensors KW - colorimetric detection KW - Peptide nucleic acids KW - PNA-masking KW - microRNAs KW - miR-145-5p KW - miRNA targeting KW - delivery KW - CFTR KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:136369758 AB - This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents. ER -