TY - THES ID - 136250796 TI - Overall survival and factors predicting long-term outcome after thoracic aortic endovascular repair AU - De Coster, Bruno AU - Maleux, Geert AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de specialistische geneeskunde (Leuven) PY - 2018 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:136250796 AB - Purpose: to assess overall survival and to determine factors predicting outcome after thoracic endovascular aortic repair. Materials and methods: Retrospective analysis, including a cohort of 212 consecutive patients (165 male and 47 female; mean age 64 years) who underwent thoracic endovascular aortic repair (TEVAR) in a tertiary referral center for aortic disease. Main indications were true thoracic aortic aneurysm (TTAA) (n=58; 27.6%), traumatic aortic rupture (n=33; 15.7%), anastomotic pseudoaneurysms (n= 23; 10.9%), dissecting thoracoabdominal aneurysm (n=22; 10.5%) and symptomatic, acute type B dissection (n=21; 10.0%). In 79 patients (37.3%), a hybrid procedure, including supra-aortic rerouting, was performed. Kaplan-Meier estimates are used for overall survival and Cox regressions models are used for univariable analysis of the association between risk factors and survival. Results: Proximal landing zones were predominantly zone 3 (n=66; 31.3%), zone 2 (n= 63; 29.9%) and zone 1 (n= 38; 18%). In-hospital mortality was n=18 (8.5%). Overall survival was 79.6%, 65.9% and 51.1% at 2, 5 and 10 years respectively; better overall survival was revealed for traumatic aortic rupture, chronic posttraumatic pseudoaneurysms and anastomotic pseudoaneurysms (P< 0.05). Clinical risk factors influencing overall survival include prior coronary bypass surgery, atrial flutter, arterial hypertension, renal failure, chronic obstructive pulmonary disease and associated abdominal aortic aneurysm (P < 0.05). Conclusions: TEVAR is an effective treatment option for various thoracic aortic diseases with highest survival rates for traumatic aortic rupture and anastomotic pseudoaneurysms. Several clinical parameters are identified as risk factors for overall survival. ER -