TY - THES ID - 136132143 TI - Videomanometry as a tool for dysphagia management in oculopharyngeal muscular dystrophy (OPMD) and sporadic inclusion body myositis (sIBM) AU - Barberis, Mara AU - Goeleven, Ann AU - Claeys, Kristl AU - Rommel, Nathalie AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master of Deglutology (Leuven) PY - 2022 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:136132143 AB - Dysphagia is common in oculopharyngeal muscular dystrophy (OPMD) and sporadic inclusion body myositis (sIBM). Timely and targeted dysphagia management is crucial to reduce risk of complications. This retrospective pilot study in 11 OPMD and 13 sIBM patients describes the pathophysiology of swallowing using videomanometry, which is the simultaneous study of videofluoroscopy and pharyngeal manometry impedance. All patients (OPMD: median age 64 years (49-79 years), 6 females, sIBM: median age 69 years (52-88 years), 7 females) were dysphagic and referred for videomanometry for further work-up. Videomanometry in OPMD showed pharyngeal hypocontractility in all patients. Disorders of upper esophageal sphincter (UES) opening and relaxation were present in 36% and 27% respectively. UES opening in OPMD was significantly reduced for a 10mL semi-solid compared to a 10mL liquid (p=0.038). In sIBM, 77% had pharyngeal weakness, combined with disorders of UES opening (54%) and UES relaxation (62%). Four sIBM patients (31%) presented with Zenker’s Diverticulum. In conclusion, dysphagia in OPMD is mainly due to pharyngeal hypocontractility, whereas in sIBM more than half of the patients presented with combined pharyngeal and UES dysfunction. In our view, dysphagia treatment is therefore more likely to be successful when targeting all affected swallow biomechanics as described by videomanometry. ER -