TY - BOOK ID - 136054415 TI - Anticancer Properties of Natural and Derivative Products AU - Lupiáñez, José Antonio AU - Pérez-Jiménez, Amalia AU - Rufino-Palomares, Eva E. PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - total phenolic content KW - total flavonoid content KW - GC-MS KW - DPPH KW - antioxidant KW - anticancer agent KW - anti-inflammatory agent KW - gingival fibroblasts KW - oral cancer KW - natural extract KW - Adenosma bracteosum KW - extract KW - anti-cancer KW - cell line KW - isolated compounds KW - caspase-3 KW - bioactive compounds KW - metabolites KW - wine KW - grapes KW - breast cancer KW - chemoprevention KW - chemotherapy KW - squamous cell carcinoma KW - Moringa oleifera KW - 3-hydroxy-β-ionone KW - antioxidant activity KW - antioxidant enzymes KW - anti-proliferative activity KW - maslinic acid KW - melanoma KW - Olea europaea L. KW - ROS levels KW - photodynamic therapy KW - cancer KW - photosensitiser KW - natural compounds KW - Elaeagnus angustifolia KW - EMT KW - apoptosis KW - AKT/PI3K signaling pathway KW - human hepatocarcinoma HepG2 cells KW - migration activity KW - proliferation KW - oxidative stress KW - ROS level KW - uvaol KW - lung metastases KW - in vivo KW - complementary medicine KW - medicinal mushrooms KW - triterpenoic acid KW - tormentic acid KW - betulinic acid KW - oleanolic acid KW - rhodamine B KW - cytotoxicity KW - hepatocellular carcinoma (HCC) KW - Pogostemon cablin (PPa extract) KW - cell cycle KW - synergism KW - natural photosensitive compounds KW - anticancer activity KW - hypericin KW - emodin KW - quinizarin KW - danthron KW - interaction KW - DNA KW - glioblastoma (GBM) KW - lactucopicrin (LCTP) KW - temozolomide (TMZ) KW - autophagy KW - NF-κB KW - p62/SQSM1 KW - natural product KW - therapeutic triglyceride KW - xenograft study KW - Caveolin-1 KW - actin cytoskeleton KW - betulin glycoconjugates KW - click chemistry KW - 1,3-dipolar cycloaddition KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:136054415 AB - Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities. ER -