TY - BOOK ID - 135765305 TI - Metabolism and Metabolomics of Liver in Health and Disease AU - Wahli, Walter AU - Guillou, Hervé PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - nonalcoholic fatty liver disease KW - nonalcoholic steatohepatitis KW - Fibrosis KW - Liver biopsy KW - Genomics KW - Metabolomics KW - Proteomics KW - Transcriptomics KW - nicotinamide KW - NAFLD KW - steatosis KW - heat stress KW - primary mouse hepatocytes KW - metabolic profile KW - GC-MS KW - multivariate statistical analysis KW - arachidonic acid KW - docosahexaenoic acid KW - inflammation KW - fibrosis KW - lipidomics KW - mass spectrometry KW - in vitro KW - HepaRG KW - sodium saccharin KW - reference toxicants KW - de novo lipogenesis KW - carbohydrate response element-binding protein KW - ChREBP KW - diabetes KW - glucose production KW - glycogen KW - glycolysis KW - glycogen storage disease type I KW - hexosamine KW - pentose phosphate pathway KW - acupuncture KW - imflammation KW - lipid metabolism KW - oxidative stress KW - metabolomics quantitative profiling KW - 1H-NMR spectroscopy KW - liver KW - bile acids KW - metabolomics KW - rat plasma KW - tandem mass spectrometry KW - liquid chromatography KW - acetaminophen KW - hepatotoxicity KW - biomarker KW - premalignant KW - alcoholic liver disease KW - cholestasis KW - cirrhosis KW - NAFL KW - NASH KW - standard operating procedures KW - urine KW - blood KW - feces KW - tissue KW - cells KW - liver function KW - nonalcoholic fatty liver KW - liquid chromatography-mass spectrometry KW - nuclear magnetic resonance spectroscopy KW - metabolic pathway KW - non-alcoholic fatty liver disease KW - non-alcoholic steatohepatitis KW - transcription factors KW - metabolic stress KW - lipid homeostasis KW - glucose homeostasis UR - https://www.unicat.be/uniCat?func=search&query=sysid:135765305 AB - Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD. ER -