TY - BOOK ID - 135765290 TI - Mitochondria in Health and Diseases AU - Javadov, Sabzali AU - Kozlov, Andrey V. AU - Camara, Amadou K.S. PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - hypoglycemia KW - sodium dichloroacetate KW - pyruvate dehydrogenase kinase KW - pyruvate dehydrogenase KW - oxidative stress KW - neuron death KW - cholangiocellular carcinoma KW - mitochondria KW - energy metabolism KW - oxidative phosphorylation KW - 4-HNE KW - DRP1 KW - ERK1/2 KW - hippocampus KW - JNK KW - mitochondrial dynamics KW - PKA KW - protein phosphatases KW - TUNEL KW - DDE KW - high-fat diet KW - mitochondrial UCP2 KW - ROS KW - antioxidant system KW - uncoupling protein KW - mitochondria: energy metabolism KW - lipid handling KW - fatty acid oxidation KW - potassium channel KW - reactive oxygen species KW - antioxidants KW - life span KW - aging KW - BKCa channels KW - pravastatin KW - gemfibrozil KW - liver KW - colon KW - mitochondrial function KW - cyclosporin A KW - mitochondria calcium buffering KW - mitochondria bioenergetics KW - mitochondria permeability transition pore KW - inorganic phosphate KW - hepatic fibrogenesis KW - HtrA2/Omi KW - reactive oxygen species stress KW - mitochondrial homeostasis KW - complex I (CI) deficiency KW - metabolome and proteome profiling KW - reactive oxygen species (ROS) KW - respirasome assembly KW - electron tunneling (ET) KW - perilipin 5 KW - lipid droplet KW - H9c2 cardiomyoblasts KW - adenine nucleotide translocase KW - respiratory supercomplexes KW - ETC complexes KW - dentate granule cell KW - epilepsy KW - hyperforin KW - LONP1 KW - neuroprotection KW - pilocarpine KW - seizure KW - siRNA KW - cardioprotection KW - mitochondrial permeability transition pores KW - mitochondrial connexin 43 KW - cardiolipin KW - iron overload KW - hepcidin KW - transferrin KW - ferritin KW - ZIP KW - inflammation KW - mtDNA KW - mitochondrial dysfunction KW - muscle aging KW - physical performance KW - LHON KW - Siberian population KW - ancient mutation KW - specific genetic background KW - apoptosis KW - human amniotic membrane KW - mitochondrial cell death KW - BAX KW - BCL-2 KW - tensile strength KW - mitochondrial gene expression KW - mtDNA transcription KW - mtRNA KW - post-transcriptional mtRNA processing KW - dsRNA KW - innate immunity KW - interferon response KW - amino acid neurotransmitter KW - cerebellar amino acid metabolism KW - hypoxia KW - 2-oxoglutarate dehydrogenase KW - tricarboxylic acid cycle KW - heart KW - cytoskeletal proteins KW - mitochondrial interactions KW - plectin KW - tubulin beta KW - signaling KW - GW9662 KW - ischemia reperfusion injury KW - Langendorff KW - myocardial KW - pioglitazone KW - redox state KW - rosiglitazone KW - TZD KW - uncoupling KW - ADP/ATP carrier KW - KmADP KW - dextran KW - morphology KW - cardiomyocytes KW - telomere length KW - telomerase activity KW - development KW - regeneration KW - intranuclear mitochondria KW - healthy cells KW - electron and confocal microscopy KW - signaling pathways KW - ion homeostasis KW - human diseases UR - https://www.unicat.be/uniCat?func=search&query=sysid:135765290 AB - Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients. ER -