TY - BOOK ID - 135723142 TI - Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - organic synthesis KW - meroterpenoids KW - thiazinoquinones KW - antiproliferative activity KW - G0/G1 cell-cycle arrest KW - cytostatic KW - solid tumor cell lines KW - alkylglycerol (AKG) KW - ricinoleic acid (RA) KW - antimicrobial activity KW - structure–activity relationship (SAR) studies KW - antibiotics (gentamicin KW - tetracycline KW - ciprofloxacin and ampicillin) KW - marine-inspired KW - breast cancer KW - bis-indoles KW - synthesis KW - apoptosis KW - carbohydrates KW - polysaccharides KW - semi-synthesis KW - sulfation KW - glycosylation KW - fucose KW - fucosylated chondroitin sulfate KW - marine natural product KW - largazole KW - HDAC inhibitors KW - modification KW - fluoro olefin KW - total synthesis KW - natural product KW - 7-deazapurine nucleoside KW - disaccharide nucleoside KW - tubercidin KW - aureol KW - tetracyclic meroterpenoids KW - natural products synthesis KW - labdane scaffold KW - bioactive diterpenes KW - sclareolide KW - structure-activity relationships KW - TRPV4 channel KW - amides/esters KW - COVID-19 KW - SARS-CoV-2 KW - lipophilic iminosugars KW - polymer-supported triphenyl phosphine KW - cholesterol KW - antibacterial iminosugars KW - n/a KW - structure-activity relationship (SAR) studies UR - https://www.unicat.be/uniCat?func=search&query=sysid:135723142 AB - Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances. ER -