TY - THES ID - 135721699 TI - High resolution manometry in patients with esophageal atresia: is esophageal dysmotility associated with clinical symptoms? AU - Van Lennep, Marinde AU - Rommel, Nathalie AU - Rayyan, Maissa AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master of Deglutology (Leuven) PY - 2022 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:135721699 AB - Background: Previously, various abnormal motility patterns in children with esophageal atresia (EA) have been described using high resolution manometry (HRM). We aimed to analyze HRM patterns in EA patients and categorize them into different degrees of dysmotility, to evaluate whether EA-related symptoms or comorbidities correlate with dysmotility or HRM parameters. Methods: Medical charts of EA patients who underwent HRM between 2016-2020 were retrospectively reviewed for EA-related symptoms and gastroesophageal reflux disease (GERD). On HRM, the proximal-, middle- and distal esophageal segment (defined as 25% upper-, 50% middle- and 25% of the distal esophagus respectively) was classified as preserved peristalsis, absent- or present contraction. HRM parameters were calculated at www.swallowgateway.com. The degree of esophageal dysmotility was then categorized into 4 groups based on the extent of preserved motility and contraction strength. Spearman correlation (rs) was used to calculate correlations between HRM outcomes and EA-symptoms. Results: HRM of 25 children (median age 1.9yrs) were analyzed. Dysmotility correlated with regurgitation (rs0.524; p=0.007) and dysphagia symptoms (rs0.437; p=0.029). Negative correlations were found between proximal motility and regurgitation (rs-0.506; p=0.010) and dysphagia (rs-0.646, p=0.000), and between distal motility and chest pain (rs-0.417; p=0.038) and regurgitation (rs-0.436; p=0.001). Pharyngeal contractile integral and esophagogastric junction resting pressure also negatively correlated with dysphagia (rs-0.422, p=0.036 vs rs-0.423, p=0.044). Conclusions: Dysphagia, chest pain and regurgitation are associated with various HRM outcomes in EA patients. More prospective studies are needed to further explore the clinical consequences of the different patterns seen. ER -