TY - BOOK ID - 135666369 TI - A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - cannabinoid KW - MRI-1867 KW - hybrid ligand KW - CB1 receptor antagonist KW - iNOS inhibitor KW - rimonabant KW - intracerebroventricular administration KW - alcohol craving KW - two-bottle paradigm KW - drinking in the dark KW - N-acyltransferase KW - anandamide KW - endocannabinoid KW - phospholipase A2 KW - cannabichromene KW - cannabidiolic acid KW - cannabidivarin KW - cannabidivarinic acid KW - phytocannabinoids KW - tetrahydrocannabivarin KW - 4′-fluoro-cannabidiol KW - cannabinoid tetrad KW - elevated plus maze KW - catalepsy KW - marble bury KW - HUF-101 KW - equilibrative nucleoside transporter KW - CB1 KW - biased signaling KW - functional selectivity KW - G-protein KW - β-arrestin KW - cannabigerol KW - anti-inflammatory KW - obesity KW - cannabinoid receptor 2 (CB2R) KW - microglia KW - inflammaging KW - memory KW - lipofuscin KW - aminoalkylindole KW - allodynia KW - antinociception KW - cannabinoid receptor KW - CP55940 KW - JWH-018 KW - K2 KW - pravadoline KW - spice KW - WIN55212-2 KW - type 1 cannabinoid receptor CB1 KW - cholesterol KW - hippocampus KW - frontal cortex KW - synaptosomes KW - rescue model KW - anti-CB1 antibody KW - cannabinoids KW - GPR55 receptors KW - VCE-006.1 KW - chromenopyrazole KW - Parkinson’s disease KW - 6-hydroxydopamine KW - lipopolysaccharide KW - amyotrophic lateral sclerosis KW - mSOD1 mice KW - TDP-43 transgenic mice KW - PPARs KW - gut microbiome KW - intestine KW - ghrelin KW - LEAP2 KW - n/a KW - 4'-fluoro-cannabidiol KW - Parkinson's disease UR - https://www.unicat.be/uniCat?func=search&query=sysid:135666369 AB - During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called “endocannabinoid system” that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas. ER -