TY - THES ID - 135602917 TI - Low-Dose Aripiprazole and Risperidone for Treating Problem Behavior in Children With Pitt-Hopkins Syndrome AU - Lambrechts, Sara AU - Danckaerts, Marina.. AU - Vogels, Annick AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de specialistische geneeskunde (Leuven) PY - 2018 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:135602917 AB - We describe two sisters with Pitt-Hopkins syndrome with a mutation in TCF4 and behavior problems who react favorably to low doses of antipsychotics. The mutation in TCF4 possibly causes an altered sensitivity of the dopaminergic system, which could explain the need for low doses with precise titration of atypical antipsychotics. ER -