TY - BOOK ID - 135602537 TI - Toxic Metals, Chronic Diseases and Related Cancers PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Trace elements KW - hair KW - children KW - hazardous waste incinerator KW - Constantí (Catalonia, Spain) KW - blood lead level KW - boatyard KW - childhood KW - lead poisoning KW - fishing community KW - lead weights KW - β2-microglobulin KW - cadmium KW - creatinine clearance KW - glomerular filtration KW - N-acetyl-β-d-glucosaminidase KW - nephron mass KW - nephrotoxicity KW - trace elements KW - autopsy tissues KW - temporal trends KW - creatinine excretion KW - glomerular filtration rate KW - lead KW - kidney KW - endocytosis KW - metallothionein KW - flow cytometry KW - proximal tubule epithelial cells KW - OGTT KW - minimal model KW - glucose response mechanism KW - genotoxicity KW - aluminum chloride KW - rats KW - food KW - farmer KW - PTWI (provisional tolerable monthly intake) KW - TWI (tolerable weekly intake) KW - Monte Carlo simulation KW - mercury KW - obesogen KW - lipid profiles KW - hyperlipidemia KW - elevated liver enzymes KW - hexavalent chromium [Cr(VI)] KW - mitochondrial fragmentation KW - dynamin-related protein 1 (Drp1) KW - mitochondrial respiratory chain complex I (MRCC I) KW - reactive oxygen species (ROS) KW - blood lead KW - cellular immunity KW - phagocytosis KW - humoral munity KW - immunosuppression KW - insulin KW - diabetes KW - hyperglycemia KW - hyperinsulinemia KW - lipogenic KW - β-cell toxicity KW - stroke KW - cerebrovascular accident KW - heavy metal KW - rare earth element KW - case-control study KW - mortality KW - lifetime cadmium intake KW - renal diseases KW - urinary cadmium KW - a follow-up study KW - diet KW - kidney function KW - chronic kidney disease KW - threshold limit KW - tolerable intake level KW - heavy metals KW - birth weight KW - preterm birth KW - diet pattern KW - Mediterranean diet KW - pregnancy KW - toxic metals KW - reproduction KW - testicular and ovarian structure KW - n/a KW - Constantí (Catalonia, Spain) UR - https://www.unicat.be/uniCat?func=search&query=sysid:135602537 AB - Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contribute to the looming statistics. Alarming evidence suggests that exposure to the heavy metal cadmium may affect every stage of life, and exposure in early life may determine susceptibility to certain diseases in adulthood. Prevention of these outcomes requires avoidance of further environmental contamination, minimization of exposure, and reduction of toxic metals in food crops to the lowest achievable levels. ER -