TY - BOOK ID - 135377848 TI - Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions AU - Lluis Fajas AU - Albert Giralt PY - 2018 PB - Frontiers Media SA DB - UniCat KW - cancer metabolism KW - proliferation KW - mitochondria KW - lipogenesis KW - metabolic adaptation KW - obesity KW - Warburg effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:135377848 AB - Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. ER -