TY - THES ID - 135165132 TI - Evaluation of sentinel node mapping with fluorescence green in cervical and endometrial cancer AU - Sprenkels, Aaron AU - Vergote, Ignace. AU - KU Leuven. Faculteit Geneeskunde. Opleiding Master in de geneeskunde (Leuven) PY - 2016 PB - Leuven KU Leuven. Faculteit Geneeskunde DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:135165132 AB - Objectives. This retrospective study demonstrates our experience with sentinel lymph node (SLN) mapping with fluorescence indocyanine green (ICG) in early stage cervical and endometrial cancer using a minimally invasive robotic approach (da Vinci®). Methods. We evaluated all cases (n=48) who underwent SLN mapping using fluorescence imaging from December 2014 to April 2016. In all cases we used ICG as a tracer. Four milliliters of diluted ICG (2 mg) of ICG was injected in the cervical stroma into four quadrants before initiating the SLN mapping. After the mapping, 27 (56.3%) cases underwent pelvic lymphadenectomy with or without para-aortic lymphadenectomy. Results. Forty-eight cases with early stage cervical (n=23) and endometrial cancer (n=25) were performed. Median age was 57 years (range, 28-80 years). The median number of SLNs harvested per patient was 3 (range, 0-7). At least one SLN was identified in 37 (77.1%) cases. Bilaterally mapping was seen in 31 (64.6%) cases, unilaterally in 6 (12.5%) cases, and none in 11 (22.9%). A para-aortic SLN was identified in 7 (18.9%) of the 37 mapped cases. Five women were found to have positive SLNs. We report one false negative case, so the false negative rate is 3.7%. In 6 (16.2%) cases, we found SLNs which contained no lymph nodes on final pathology (false positive mapping). The sensitivity and spe¬cificity for SLN mapping with ICG is 80% and 100%. The negative predictive value (NPV) is 94.7%. Conclusions. In our experience, fluorescence imaging with intracervical ICG injection using the ro¬botic approach shows good results in terms of overall detection rate, bilateral detection rate and false negative rate. Our results justifies performing studies with larger patient numbers. ER -