TY - BOOK ID - 134860261 TI - Drug Metabolism/Transport and Pharmacokinetics PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - tofacitinib KW - dose-dependent pharmacokinetics KW - hepatic and intestinal first-pass effect KW - rats KW - catalposide KW - in vitro human metabolism KW - UDP-glucuronosyltransferase KW - sulfotransferase KW - carboxylesterase KW - celecoxib KW - drug–drug interaction KW - fluorescence KW - HPLC KW - metabolism KW - repaglinide KW - HSG4112 KW - anti-obesity agent KW - stereoselectivity KW - pharmacokinetics KW - compound K KW - protopanaxadiol (PPD) KW - biliary excretion KW - intestinal metabolism KW - Carthamus tinctorius extract KW - notoginseng total saponins KW - comparative pharmacokinetic study KW - large volume direct injection KW - compatibility mechanism KW - mertansine KW - human hepatocytes KW - cytochrome P450 KW - UDP-glucuronosyltransferases KW - sodium-glucose cotransporter 2 (SGLT2) inhibitors KW - DWP16001 KW - kidney distribution KW - inhibition mode KW - diabetes KW - transporter-enzyme interplay KW - influx transporter KW - efflux transporter KW - physiologically based pharmacokinetic model KW - cytochrome P450 enzymes KW - tiropramide KW - healthy Korean subjects KW - modeling KW - population pharmacokinetic KW - quercetin KW - breast cancer resistance protein KW - inhibitor KW - prazosin KW - sulfasalazine KW - kinetic analysis KW - food–drug interactions KW - Caco-2 KW - EpiIntestinal KW - first-pass KW - P-gp KW - BCRP KW - drug transporter KW - CYP3A4 KW - oral availability KW - automatization KW - drug absorption KW - drug dosing KW - head-and-neck cancer KW - real-time measurements KW - taxanes KW - tissue engineering KW - UHPLC-MS/MS KW - metformin KW - verapamil KW - drug interaction KW - organic cation transporter 2 KW - renal excretion KW - acute renal failure KW - gentamicin KW - cisplatin KW - hepatic CYP3A1(23) KW - creatinine clearance KW - renal clearance KW - nonrenal clearance UR - https://www.unicat.be/uniCat?func=search&query=sysid:134860261 AB - This book serves to highlight the pharmacokinetics/drug–drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters. ER -