TY - BOOK ID - 134316564 TI - Molecular imaging in Parkinson's Disease PY - 2011 PB - Firenze : Firenze University Press, DB - UniCat KW - Parkinson's disease. UR - https://www.unicat.be/uniCat?func=search&query=sysid:134316564 AB - The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Florence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus. ER -