TY - BOOK ID - 134292068 TI - Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II AU - Spetea, Mariana AU - van Rijn, Richard M. PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Chemistry KW - thiazole KW - piperazine KW - tail-clip KW - hot-plate KW - acetic acid-induced writhing test KW - opioid KW - prodynorphin KW - epigenetics KW - transcription KW - human brain KW - morphine dosing KW - behavior KW - locomotor activity KW - tolerance KW - µ-opioid receptor KW - DAMGO KW - SR-17018 KW - buprenorphine KW - nalbuphine KW - kappa opioid receptor agonist KW - pruritis KW - scratching KW - mice KW - TAT-HIV KW - cholestasis KW - chloroquine KW - deoxycholic acid KW - analgesic KW - δ opioid receptor KW - G-protein-biased agonist KW - opioid peptide KW - rubiscolins KW - µ-opioid analgesics KW - angiotensin receptors KW - chronic pain KW - neuropathic pain KW - delta opioid receptor KW - inverse agonist KW - irreversible antagonist KW - non-competitive antagonist KW - molecular pharmacology KW - free fatty acid receptors KW - lipids KW - opioid receptor KW - colitis KW - chemotype KW - high-throughput screen KW - allosteric modulation KW - beta-arrestin KW - molecular dynamics KW - opioid receptors KW - β-amino acids KW - peptide synthesis KW - receptor binding studies KW - functional assay KW - nociceptin/orphanin FQ receptor KW - NOP receptor KW - ligands KW - nociceptin KW - N/OFQ KW - analgesia KW - GPCR KW - HS-731 KW - peripheral opioid agonist KW - binding KW - selectivity KW - molecular docking KW - molecular dynamics simulations KW - n/a KW - fluorescence cross-correlation spectroscopy (FCCS) KW - G protein-coupled receptor (GPCR) KW - serotonin UR - https://www.unicat.be/uniCat?func=search&query=sysid:134292068 AB - Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role. ER -