TY - BOOK ID - 134101595 TI - Preclinical Evaluation of Lipid-Based Nanosystems AU - Silva, Ana Catarina AU - Sousa Lobo, José Manuel PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Technology: general issues KW - nanostructured lipid carriers (NLC) KW - formulation optimization KW - rivastigmine KW - quality by design (QbD) KW - nasal route KW - nose-to-brain KW - N-alkylisatin KW - liposome KW - urokinase plasminogen activator KW - PAI-2 KW - SerpinB2 KW - breast cancer KW - liposomes KW - target delivery nanosystem KW - FZD10 protein KW - colon cancer therapy KW - supersaturation KW - silica-lipid hybrid KW - spray drying KW - lipolysis KW - lipid-based formulation KW - fenofibrate KW - mesoporous silica KW - oral drug delivery KW - hyaluronic acid KW - drug release KW - light activation KW - stability KW - mobility KW - biocorona KW - dissolution enhancement KW - phospholipids KW - solid dosage forms KW - porous microparticles KW - nanoemulsion(s) KW - phase-behavior KW - DoE KW - D-optimal design KW - vegetable oils KW - non-ionic surfactants KW - efavirenz KW - flaxseed oil KW - nanostructured lipid carriers KW - nanocarrier KW - docohexaenoic acid KW - neuroprotection KW - neuroinflammation KW - fluconazole KW - Box‒Behnken design KW - nanotransfersome KW - ulcer index KW - zone of inhibition KW - rheological behavior KW - ex vivo permeation KW - nanomedicine KW - cancer KW - doxorubicin KW - melanoma KW - drug delivery KW - ultrasound contrast agents KW - phospholipid coating KW - ligand distribution KW - cholesterol KW - acoustic response KW - microbubble KW - lipid phase KW - dialysis KW - ammonia KW - intoxication KW - cyanocobalamin KW - vitamin B12 KW - atopic dermatitis KW - psoriasis KW - transferosomes KW - lipid vesicles KW - skin topical delivery KW - oligonucleotide KW - self-emulsifying drug delivery systems KW - hydrophobic ion pairing KW - intestinal permeation enhancers KW - Caco-2 monolayer KW - clarithromycin KW - solid lipid nanoparticles KW - optimization KW - permeation KW - pharmacokinetics KW - follicular targeting KW - dexamethasone KW - alopecia areata KW - lipomers KW - lipid polymer hybrid nanocapsules KW - biodistribution KW - skin KW - ethyl cellulose KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:134101595 AB - The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area. ER -