TY - BOOK ID - 134101588 TI - Appetite and Satiety Control-Gut Mechanisms AU - Feinle-Bisset, Christine AU - Horowitz, Michael PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - lixisenatide KW - intragastric meal retention KW - energy intake KW - type 2 diabetes KW - obesity KW - amino acid KW - isoleucine KW - chronic supplementation KW - energy expenditure KW - oral glucose tolerance test KW - glycaemic control KW - gastric emptying breath test KW - endocannabinoid KW - cannabinoid CB1 receptor KW - gut–brain KW - intestine KW - western diet KW - preference KW - whey protein KW - gastric emptying KW - appetite KW - lifecourse KW - gut hormones KW - hunger KW - protein KW - TAS2R5 KW - TAS2R39 KW - TAS2R14 KW - agonist KW - food intake KW - GLP1 KW - CCK KW - PYY KW - miniature pig KW - pig model KW - functional brain imaging KW - molecular imaging KW - vagal afferents KW - single fiber recording KW - insulin resistance KW - GLP-1r KW - gastric barostat KW - scintigraphy KW - meal ingestion KW - postprandial responses KW - hedonic sensations KW - homeostatic sensations KW - abdominal wall activity KW - abdominal distension KW - taste KW - fat KW - carbohydrate KW - bariatric surgery KW - GLP-1 KW - ghrelin KW - Roux-en-Y gastric bypass KW - gastric band KW - sleeve gastrectomy KW - circadian KW - gastrointestinal tract KW - enteroendocrine cells KW - chemosensory KW - GIP KW - nutrients KW - hormones KW - food ingestion KW - digestion KW - satiety KW - digestive well-being KW - functional gastrointestinal disorders KW - postprandial symptoms KW - brainstem KW - vagus KW - feeding KW - gastrointestinal KW - cue reactivity KW - meal anticipation KW - motivation KW - nutrient preference KW - flavor KW - aversion KW - bile acids KW - TGR-5 KW - FXR KW - gastrointestinal hormones KW - body weight KW - gastric accommodation KW - satiation KW - CB1 receptor KW - gut-brain KW - reward KW - aging KW - whey KW - anorexia KW - supplements KW - sarcopenia KW - nutrient sensing KW - enteroendocrine cells (EECs) KW - appetite regulation KW - G-protein coupled receptors (GPCRs) KW - bitter substances KW - gastric motor function KW - postprandial blood glucose KW - preclinical studies KW - human studies KW - texture KW - oro-sensory exposure KW - sensory science KW - cephalic responses KW - brain areas KW - brain stem KW - weight management KW - intestinal brake KW - duodenal jejunal and ileal brake KW - tastants KW - circadian clock KW - gastric bypass surgery KW - microbiome KW - hypothalamus KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:134101588 AB - The prevalence of obesity and its comorbidities, particularly type 2 diabetes, cardiovascular and hepatic disease and certain cancers, continues to rise worldwide. Paradoxically, despite an increasingly obesogenic environment, particularly in Western societies, undernutrition is also extremely common. The application of novel, sophisticated techniques, particularly related to imaging and molecular biology, has substantially advanced our understanding of the mechanisms controlling appetite and energy intake. This has led to a redefinition of many concepts, including the relative importance of central versus peripheral mechanisms, recognising that the gastrointestinal (GI) tract, particularly gut hormones, plays a critical role. Given the major advance in knowledge in the field, this Special Issue provides a comprehensive overview of the GI mechanisms underlying the regulation of appetite and energy intake, as a series of definitive reviews by international authorities. The reviews address gut-related mechanisms, including nutrient sensing, gut hormones and GI motility, gut-brain communication, including the roles of the vagus and the modulation of reward perception, the roles of diet and the microbiota, as well as the abnormalities associated with eating disorders, specifically obesity and anorexia of ageing, and the beneficial effects of bariatric surgery. The reviews cover both preclinical research and studies in humans, and are complemented by a number of important original papers. ER -