TY - BOOK ID - 134099774 TI - Clay-Based Pharmaceutical Formulations and Drug Delivery Systems PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - hydrochlorothiazide KW - cyclodextrins KW - sepiolite KW - nanoclay KW - dissolution rate KW - tablet KW - electrospinning KW - chitosan KW - chondroitin sulfate KW - scaffolds KW - montmorillonite KW - halloysite KW - fibroblasts proliferation KW - immune response KW - glycosaminoglycans KW - antimicrobial properties KW - palygorskite KW - spring water KW - hydrogel KW - fibroblast KW - biocompatibility KW - wound healing KW - mesoporous clay KW - Neusilin KW - aeroperl KW - liquisolid technique KW - glyburide KW - dissolution improvement KW - hydrotalcite KW - ketoprofen KW - hybrid KW - photostability KW - hydrogel film KW - bioadhesion KW - heavy metal KW - hazardous element KW - element mobility KW - clay minerals KW - toxicity KW - palygorksite KW - proliferation KW - Franz cell KW - bioactive elements KW - praziquantel KW - drug KW - organic solvents KW - in vitro dissolution tests KW - cytotoxicity KW - targeted drug delivery KW - halloysite nanotube KW - osteosarcoma KW - methotrexate KW - surface modification KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:134099774 AB - This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design. ER -