TY - BOOK ID - 134039825 TI - Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Chemistry KW - Organic chemistry KW - multi-component reaction KW - fusidic acid KW - TEMPO-conjugate KW - electron paramagnetic resonance (EPR) spectroscopy KW - caspase-3 KW - incomptine A KW - sesquiterpene lactone KW - Decachaeta incompta KW - cytotoxic activity KW - iTRAQ KW - apoptosis KW - ROS production KW - violacein KW - hepatocellular carcinoma KW - proliferation KW - stemness KW - natural products KW - tumor microenvironment (TME) KW - lung cancer KW - phytochemicals KW - botanical agents KW - steroidal alkaloids KW - solanidane alkaloids KW - demissidine KW - solanidine KW - flavonoids KW - coronavirus KW - SARS-CoV-2 KW - SARS-CoV KW - MERS-CoV KW - anticancer activity KW - apoptosis resistance KW - ophiobolin A KW - polygodial KW - Wittig reaction KW - melanoma KW - tumor heterogeneity KW - pregnancy KW - anti-tumor peptides KW - in vitro model KW - medicinal herbs KW - cancer treatment KW - cancer stem cells KW - drug resistance KW - metastasis KW - RCE-4 KW - PCD KW - ATG 4B KW - the Bcl-2–Beclin 1 complex KW - Sparticola junci KW - structure elucidation KW - ECD-TDDFT KW - COX inhibitory KW - molecular docking KW - antiproliferative KW - cytotoxic KW - Sepedonium ampullosporum KW - peptaibols KW - ampullosporin KW - glutamic acid methyl ester KW - solid-phase peptide synthesis KW - antifungal KW - anticancer KW - target identification KW - kaempferol KW - docking KW - DARTS KW - Src KW - breast cancer KW - butein KW - frondoside-A KW - STAT3 KW - angiogenesis KW - invasion KW - viability KW - tumor growth KW - marine fungi KW - Cosmospora sp. KW - soudanone KW - Magnaporthe oryzae KW - co-culture KW - phytopathogen KW - molecular networking KW - metabolomics KW - bispecific antibody KW - Trypsiligase KW - click chemistry KW - biorthogonal chemistry KW - antibody engineering KW - n/a KW - the Bcl-2-Beclin 1 complex UR - https://www.unicat.be/uniCat?func=search&query=sysid:134039825 AB - Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs. ER -