TY - BOOK ID - 133647965 TI - The Advances and Applications of Optogenetics AU - Govorunova, Elena G. AU - Sineshchekov, Oleg A. PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - optogenetic tools KW - neuroscience KW - calcium sensor KW - voltage sensor KW - neurotransmitters KW - optogenetics KW - channelrhodopsins KW - sodium KW - calcium KW - DC gate KW - Optogenetics KW - p53 KW - AsLOV2 KW - LINuS KW - LEXY KW - MIP KW - PMI KW - Chlamydomonas reinhardtii KW - ion channel KW - electrophysiology KW - molecular dynamics simulations KW - membrane-protein interaction KW - energy of membrane deformation KW - CTMD method, residual hydrophobic mismatch KW - microbial rhodopsin KW - channelrhodopsin KW - membrane current KW - hippocampal neurons KW - light stimulation KW - channelrhodopsin-2 KW - photoreceptor KW - BLUF KW - modular domain KW - resonance Raman KW - flash photolysis KW - hybrid QM/MM simulation KW - two-photon KW - azobenzene KW - photoswitch KW - photoswitching KW - photocontrol KW - all-optical electrophysiology KW - microbial rhodopsins KW - ion channels KW - LOV domains KW - membrane potential KW - intracellular trafficking KW - protein–protein interaction KW - signaling UR - https://www.unicat.be/uniCat?func=search&query=sysid:133647965 AB - This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research. ER -