TY - BOOK ID - 133491195 TI - From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials AU - FESSARD, Valérie AU - Nesslany, Fabrice PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Humanities KW - Social interaction KW - graphene oxide KW - reduced graphene oxide KW - micronucleus KW - oxidative stress KW - safer-by-design KW - tungsten KW - nanoparticles KW - tritiated particles KW - in vitro testing KW - cytotoxicity KW - micronuclei formation KW - DNA damage KW - epigenetics KW - DNA methylation KW - BEAS-2B cells. KW - polystyrene nanoparticles KW - nanoplastics KW - genotoxicity KW - Hs27 human fibroblasts KW - comet assay KW - FPG enzyme KW - TiO2NP KW - SiO2NP KW - ZnONP KW - CeO2NP KW - AgNP KW - multi-walled carbon nanotubes (MWCNT) KW - titanium dioxide nanoparticles KW - lincomycin KW - human amniotic cells KW - in vitro genotoxicity KW - apoptosis KW - nanotoxicology KW - metal oxides KW - high throughput screening KW - micronucleus assay KW - nanomaterial KW - aluminum KW - oral route KW - gut KW - liver KW - V79 cells KW - Hprt KW - advanced in vitro model KW - hepatotoxicity KW - liver spheroids KW - 3D culture KW - HepG2 KW - nongenotoxic silver nanoparticles KW - genotoxic KW - cytotoxic KW - antioxidant activity KW - silver ions KW - Allium cepa KW - metal/coating agent ratio KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:133491195 AB - This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools. ER -