TY - BOOK ID - 133465684 TI - Immunotherapy, Tumor Microenvironment and Survival Signaling PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - Clinical & internal medicine KW - Autophagy KW - colorectal cancer KW - immunotherapy KW - tumor stroma KW - tumor microenvironment KW - immune checkpoint inhibitors KW - chemotherapy KW - tyrosine kinase inhibitors KW - angiogenesis KW - check point inhibitors KW - programmed cell death protein 1 KW - programmed cell death 1 ligand 1 KW - cardiotoxicity KW - lung metastasis KW - CAR-T KW - hypoxia KW - tumor KW - microenvironment KW - CD19 KW - BCMA KW - cancer KW - melanoma KW - immune escape KW - antigen loss KW - chimeric antigen receptor KW - electroporation KW - lentivirus KW - lentiviral transduction KW - macrophages KW - leukemia cells KW - lytic peptides KW - targeted therapy KW - dendritic cells KW - pathogenesis KW - risk factors KW - breast cancer KW - resistance KW - checkpoint KW - targeted treatment KW - personalized medicine KW - pediatric solid tumors KW - chimeric antigen receptors KW - cancer vaccines KW - oncolytic viral therapy KW - immunomodulation KW - DCLK1 KW - tumor stem cells KW - clonogenicity KW - mitochondria KW - mitochondrial transfer KW - tunneling nanotubes KW - triple-negative breast cancer KW - immune checkpoint inhibitor KW - combination therapy KW - cancer nanomedicine KW - tumor antigens KW - cancer metabolism KW - cancer immunotherapy KW - nanoparticles KW - immunotherapeutic agent KW - immunomodulators KW - tuft cells KW - cancer stem cells KW - immunotherapies KW - myeloid-derived suppressor cells KW - regulatory T cells KW - crosstalk KW - tumor immune evasion KW - cell–cell contact KW - β2 integrins KW - CD18 KW - CD11 KW - CAR-T cells KW - CD37 KW - cell therapy KW - tumor antigen KW - lymphoma KW - CAR macrophage KW - CAR T cell KW - solid tumors KW - immunometabolism KW - miRNA KW - immunogenic cell death KW - n/a KW - cell-cell contact UR - https://www.unicat.be/uniCat?func=search&query=sysid:133465684 AB - The book is based on the Cancers journal Special Issue entitled “Immunotherapy, Tumor Microenvironment and Survival Signaling", and focuses on important problems concerning tumors and tumor microenvironment interactions, as well as novel immunotherapies such as CAR-T cell therapy. Immunotherapies have recently shown remarkable results in the treatment of cancer patients. However, there are still many questions that remain to be solved in regards to more effective therapies, such as the tumor heterogeneous profile, tumor microenvironment, and tumor survival epigenetic and genetic pathways, all of which make patients resistant to the presently available treatments for cancer. This book demonstrates different approaches to overcome the challenges faced by immunotherapies due to suppressive tumor microenvironments. This book includes 18 papers that can be divided into three chapters: 1. novel immunotherapies; 2. targeting tumor microenvironment and novel approaches; 3. targeting tumors and tumor microenvironment in different types of cancer. ER -