TY - BOOK ID - 133454294 TI - Antitumoral Properties of Natural Products : Volume 2 PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - cytotoxic activity KW - NCI-60 cancer cell line KW - pristimerin KW - Salacia crassifolia KW - Celastraceae KW - Brazilian Cerrado biome KW - Salacia elliptica KW - Cheiloclinium cognatum KW - Plenckia populnea KW - Aspergillus fumigatus KW - Cordyceps sinensis KW - isochromanes KW - chiral resolution KW - ECD calculation KW - cytotoxicity KW - coronarin D KW - JNK KW - osteosarcoma KW - Zeylenone KW - gastric cancer KW - invasion KW - migration KW - apoptosis KW - anti-cancer agents KW - anthraquinones KW - glycosyltransferase KW - Dendrobium officinale KW - structure elucidation KW - anti-tumor activity KW - plantation mode KW - AR KW - Ganoderma tsugae KW - lipogenesis KW - prostate cancer KW - SREBP-1 KW - ursolic acid KW - betulinic acid KW - triterpenoids KW - necrotic KW - quercetin KW - quercetagetin KW - patuletin KW - lichen KW - secondary metabolites KW - tumidulin KW - stemness potential KW - colorectal cancer cells KW - oncogene KW - transcriptional regulation KW - neferine KW - FAK/S6K1 KW - autophagy KW - human neuroblastoma cells KW - natural yellow Monascus pigments KW - water-soluble KW - antioxidation KW - MCF-7 cells KW - phloretin KW - cell proliferation KW - inflammation KW - glucose uptake KW - Catalpa speciosa KW - Taxus cuspidata KW - Magnolia acuminata KW - phenols KW - antioxidants KW - anticancer KW - Colocasia esculenta KW - food bioactive KW - tarin KW - stable nanocapsules KW - entrapment efficiency KW - no-toxicity KW - preclinical tests KW - antitumoral activity KW - chemotherapeutic adjuvant KW - grape leaves KW - ASE KW - TP KW - Antioxidant activities KW - Antiproliferative KW - pro-apoptotic effects KW - Gene expression KW - Nutraceuticals KW - Cucurbitacin B KW - gefitinib-resistant NSCLC KW - EGFR KW - lysosomal degradation KW - CIP2A KW - zerumbone KW - cancer KW - NF-κB KW - IL-6/JAK2/STAT3 KW - Akt KW - FOXO1 KW - multiple myeloma KW - quality control KW - naringenin KW - flavonoids KW - traditional preparation KW - cancer stem cells KW - phytochemicals KW - plant-derived foods KW - fruit KW - vegetable KW - cell signaling KW - Artemisia absinthium KW - endoplasmic reticulum stress KW - mitochondrial-dependent pathway KW - melanoma KW - bee venom KW - melittin KW - temozolomide KW - AKT KW - MAPK KW - antrodin C KW - mTOR KW - metabolic stability KW - capsazepine KW - inflammatory diseases KW - ROS KW - TRPV1 KW - PI3K/AKT/mTOR KW - CLE-10 KW - LC3 KW - MDA-MB-231 KW - lactoferrin hydrolysate KW - copper KW - manganese KW - gastric cancer cells KW - anti-cancer activity KW - molecular mechanism KW - natural product alkaloids KW - cephalotaxine KW - protein synthesis inhibition KW - antiproliferation agents KW - folk medicine KW - DLD-1 cells KW - doxorubicin KW - chemotherapy KW - drug resistance KW - CrataBL KW - glioblastoma KW - mesenchymal stem cells KW - microenvironment KW - plant lectin KW - protease inhibitor KW - cryptolepine KW - neocryptolepine KW - isocryptolepine KW - antiproliferative activity KW - structure activity relationships KW - Licochalcone A KW - ATM-Chk2 KW - 13-ethylberberine KW - mitochondrial ROS KW - RT-R breast cancer cells KW - diallyl disulfide KW - PI3K/Akt/mTOR pathway KW - Pulsatilla saponin D KW - SB365 KW - glioblastoma multiforme KW - autophagic flux inhibition KW - lysosomal membrane permeabilization KW - mitochondrial membrane potential KW - CLEFMA KW - p38 KW - proanthocyanins KW - TNF-α KW - lung adenocarcinoma KW - natural compounds KW - cervical cancer KW - cell cycle arrest KW - dicentrine KW - metastasis KW - glioma KW - semi-synthetic derivative KW - ingenol KW - Euphorbia tirucalli KW - protein kinase C KW - seaweed KW - porphyran KW - carrageenan KW - anti-cancer KW - natural products KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:133454294 AB - Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment. ER -