TY - BOOK ID - 133375081 TI - Bioinorganic Chemistry of Nickel AU - Maroney, Michael J. AU - Ciurli, Stefano PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - InrS KW - nickel-dependent transcriptional regulators KW - molecular modelling KW - nickel KW - hydrogenase KW - urease KW - Ni-enzymes KW - pathogens KW - ncRNA KW - miRNA KW - lncRNA KW - lung carcinogenesis KW - histidine-rich protein KW - carbon monoxide dehydrogenase KW - nickel chaperone KW - nickel-induced oligomerization KW - urease maturation KW - metallochaperone KW - G-protein KW - conformational change KW - bioavailability KW - carcinogenicity KW - genotoxicity KW - allergy KW - reproductive KW - asthma KW - nanoparticles KW - ecotoxicity KW - environment KW - biological nickel sites KW - nickel-thiolates KW - dinuclear nickel metallopeptides KW - thiolate oxidative damage KW - nickel enzymes KW - reaction mechanism KW - quantum chemical calculations KW - glyoxalase KW - streptomyces KW - mycothiol KW - metalloenzyme KW - AD11 KW - nickel-dependent enzyme KW - methionine salvage pathway KW - methionine KW - S-adenosylmethionine (SAM) KW - methylthioadenosine (MTA) KW - enolase phosphatase 1 (ENOPH1) KW - polyamine KW - matrix metalloproteinase MT1 (MT1-MMP) KW - metalloregulator KW - chaperone KW - [NiFe]-hydrogenase KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:133375081 AB - The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology. ER -