ID - 131910163 TI - Tight Junctions PY - 2022 SN - 9783030972042 9783030972035 9783030972059 9783030972066 PB - Cham Springer International Publishing DB - UniCat KW - Histology. Cytology KW - Biology KW - History of human medicine KW - Pathological biochemistry KW - Neuropathology KW - Human medicine KW - medische biochemie KW - neurologie KW - farmacologie KW - biologie KW - biomedische wetenschappen KW - cytologie KW - histologie KW - Tight junctions (Cell biology) KW - Life sciences. KW - Citologia UR - https://www.unicat.be/uniCat?func=search&query=sysid:131910163 AB - This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research. ER -